Dana Wolf, MD
Professor and Head, Clinical Virology
Hadassah Hebrew University Medical Center
Dana Wolf is a Professor of Virology and Infectious Diseases at the Hebrew University, Jerusalem, Israel, and a Senior Infectious Diseases Physician at the Hadassah University Hospital.
She received her M.D. degree at the Hebrew University Hadassah Medical School, and completed her Internal Medicine residency and her fellowship in Infectious Diseases at the Hadassah University Hospital. She pursued a postdoctoral fellowship in Virology at the University of California San Diego and later spent a year as a visiting scientist at Stanford University.
Since 2002 - she is the Director of Clinical Virology at Hadassah.
Dr. Wolf is a member of several national and international advisory committees and boards, including the Advisory Committee on Immunization Practices and Infectious Diseases in Israel, and the European Society for Virology Executive Board. She is a member of the Lautenberg Center for General and Tumor Immunology, and has been an active partner in several EU Consortiums.
Research Group Activity
Dr. Wolf's lab further focuses on the discovery and evaluation of novel antiviral drugs and drug targets, and on the mechanism and impact of HCMV antiviral drug resistance.
In her studies within the frame of the Infect Era consortium she explores how distinct maternal antibodies interact with HCMV within the local immune environment of the human materno-fetal interface
Her studies have focused on human cytomegalovirus (HCMV) transmission and pathogenesis in the materno-fetal interface; employing a unique ex vivo human placental model, she has characterized the mode of maternal-to-fetal viral spread and the impact of placental innate immune responses and new antiviral approaches on the outcome of congenital infection. More recently, she has also studied Zika virus infection and virus-specific innate immune responses in the human placenta. In her clinical-diagnostic studies, she is interested in the epidemiology and early prenatal and neonatal detection of congenital HCMV infection and disease.
Weisblum Y, A Panet, Z Zakay-Rones, R Haimov-Kochman, D Goldman-Wohl, I Ariel, H Falk, S Natanson-Yaron, MD Goldberg, R Gilad, NS Lurain, C Greenfield, S Yagel, DG Wolf. Modeling of human cytomegalovirus (HCMV) maternal-fetal transmission in a novel decidual organ culture. 2011 Journal of Virology 85:13204-13. (Selected for the Faculty of 1000 (F-1000) library of the top 2% of published articles in biology and medicine).
Weisblum Y, A Panet, R Haimov-Kochman, DG Wolf. Models of vertical cytomegalovirus (CMV) transmission and Pathogenesis. 2014 Seminars in Immunopathology 36:615-25.
Weisblum Y, A Panet , Z Zakay-Rones, A Vitenshtein, R Haimov-Kochman, D Goldman-Wohl, E Oiknine Djian, R Yamin, K Meir, H Amsalem, T Imbar, O Mandelboim, S Yagel, DG Wolf. Human cytomegalovirus induces a distinct innate immune response in the maternal-fetal interface. 2015 Virology 485:289-296.
Berger AA, Y Gil, A Panet, Y Weisblum, E Oiknine-Djian, M Gropp, D Steiner, BE Reubinoff, DG Wolf. Transition toward Human Cytomegalovirus Susceptibility in Early Human Embryonic Stem Cell-Derived Neural Precursors. 2015 Journal of Virology 89:11159-64.
Weisblum Y, E Oiknine-Djian, OM Vorontsov, R Haimov-Kochman, Zakay- Z Rones, K Meir, D Shveiky, S Elgavish, Y Nevo, M Roseman, M Bronstein, D Stockheim, I From, I Eisenberg, AA Lewkowicz, S Yagel, A Panet, DG Wolf. Zika Virus Infects Early- and Midgestation Human Maternal Decidual Tissues, Inducing Distinct Innate Tissue Responses in the Maternal-Fetal Interface. 2017 Journal of Virology 91. pii: e00785-17. doi: 10.1128/JVI.00785-17.
Glasner A, E Oiknine-Djian, Y Weisblum, M Diab, A Panet, DG Wolf, O Mandelboim. Zika virus escapes NK cell detection by upregulating MHC class I molecules. 2017 Journal of Virology pii:JVI.00785-17. doi: 10.1128/JVI.00785-17.
Weisblum Y, E Oiknine-Djian, Z Zakay-Rones, O Vorontsov, R Haimov-Kochman, Y Nevo, D Stockheim, S Yagel, A Panet, DG Wolf. APOBEC3A is Upregulated by Human Cytomegalovirus in the Maternal-Fetal Interface, Acting as an Innate Anti-HCMV Effector. 2017 Journal of Virology pii:JVI.01296-17. doi: 10.1128/JVI.01296-17.